Polymer effects modulate binding affinities in disordered proteins
نویسندگان
چکیده
منابع مشابه
Predicting Binding Regions within Disordered Proteins.
Disordered regions are sequences within proteins that fail to fold into a fixed tertiary structure and have been shown to be involved in a variety of biological functions. We recently applied neural network predictors of disorder developed from X-ray data to several protein sequences characterized as disordered by NMR (Garner, Cannon, Romero, Obradovic and Dunker, Genome Informatics, 9:201-213,...
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Many disordered proteins function via binding to a structured partner and undergo a disorder-to-order transition. The coupled folding and binding can confer several functional advantages such as the precise control of binding specificity without increased affinity. Additionally, the inherent flexibility allows the binding site to adopt various conformations and to bind to multiple partners. The...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1904997116